Michel Vorm will be hoping to get his World Cup off to a flying start when the Netherlands face Spain tonight (8pm BST).
The two sides, who famously met in the 2010 final in South Africa, go head to head in Salvador as Group B gets underway.
Vorm will be looking to take his place in goal for Louis van Gaal's side, while Jonathan de Guzman has overcome a slight hamstring problem to put forward his case for selection.
Wilfried Bony is also in action this weekend as the Ivory Coast take on Japan.
The Group C opener at Arena Pernambuco in Recife kicks off at 2am BST on Sunday (June 15).
Meanwhile, Ki Sung-Yueng will have to wait until Tuesday to get his first taste of the tournament as South Korea kick off their Group H campaign against Russia in Cuiaba.